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Zhang et al. show that CD8+ T cells enhance PPAR-α signaling and fatty acid catabolism under the hypoglycemic and hypoxic condition to partially preserve effector functions. Metabolic reprogramming of T cells using a PPAR-α agonist improves tumor growth control, which is enhanced in combination with PD-1 blockade.

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Dr. Chi Zhang, MD is a gastroenterology specialist in North Adams, MA and has been practicing for 28 years. He graduated from China Med University In Shenyang in 1990 and specializes in gastroenterology.

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